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2025-06-19 
灵灵一产品：Coding sequence of Spry1（p35485）
Zhichao Liu;Yaru Zhang;Ning Ma;Yang Yang;Yunlong Ma;Feng Wang;Yan Wang;Jinzhi Wei;Hongyan Chen;Alfredo Tartarone;Jeffrey B. Velotta;Farshid Dayyani;Emmanuel Gabriel;Connor J. Wakefield;Biniam Kidane;Cristiano Carbonelli;Lingyun Long;Zhihua Liu;Jianzhong Su;Zhigang Li,Progenitor-like exhausted SPRY1 CD8 T cells potentiate responsiveness to neoadjuvant PD-1 blockade in esophageal squamous cell carcinoma,2023-10-12,DOI:10.1016/j.ccell.2023.09.011
IF:48.8
链接：https://doi.org/10.1016/j.ccell.2023.09.011
产品：pLVX-EnCMV-EGFR(human)-FLAG-PGK-Puro-WPRE（P7777）
Feng Lin, Shenyi Yin, Zijian Zhang, Ying Yu, Haoming Fang, Zhen Liang, Rujie Zhu, Haitao Zhou, Jianjie Li, Kunxia Cao, Weiming Guo, Shan Qin, Yuxuan Zhang, Chenghao Lu, Han Li, Shibo Liu, Heng Zhang, Buqing Ye, Jian Lin, Yan Li, Xiaozheng Kang, Jianzhong Jeff Xi, Peng R Chen,Multimodal targeting chimeras enable integrated immunotherapy leveraging tumor-immune microenvironment,2024-11-05,DOI:10.1016/j.cell.2024.10.016
IF:45.6
链接：https://doi.org/10.1016/j.cell.2024.10.016
产品：HA-tagged STAT1 plasmid（P19480）
Yinghua Zhao; Liyan Sui; Ping Wu; Wenfang Wang; Zedong Wang; Yang Yu; Zhijun Hou; Guangyun Tan; Quan Liu; Guoqing Wang,A dual-role of SARS-CoV-2 nucleocapsid protein in regulating innate immune response,2021-4-3,DOI:10.1038/s41392-021-00742-w
IF:40.8
链接：https://doi.org/10.1038/s41392-021-00742-w
产品：HA-tagged STAT1 plasmid（P19480）
Yinghua Zhao;Liyan Sui;Ping Wu;Wenfang Wang;Guangyun Tan;Zedong Wang;Yang Yu;Zhijun Hou;Guoqing Wang;Quan Liu,SARS-CoV-2 nucleocapsid protein dually regulates innate immune responses,2021-2-18,DOI:10.1101/2021.02.17.431755
IF:40.8
链接：https://doi.org/10.1101/2021.02.17.431755
Cheng Cheng;Qingrui Zha;Linmao Sun;Tianming Cui;Xinyu Guo;Changjian Xing;Zhengxiang Chen;Changyong Ji;Shuhang Liang;Shengwei Tao;Junhui Chu;Chenghui Wu;Qi Chu;Xuetian Gu;Ning Zhang;Yumin Fu;Shumin Deng;Yitong Zhu;Jiabei Wang;Yao Liu;Lianxin Liu,VCP downstream metabolite glycerol-3-phosphate (G3P) inhibits CD8+T cells function in the HCC microenvironment,2025-1-24,DOI:10.1038/s41392-024-02120-8
IF:40.8
链接：https://doi.org/10.1038/s41392-024-02120-8
产品：pLV3-CMV-OVAL(chicken)-CopGFP-Puro（p43339）
Cheng Cheng;Qingrui Zha;Linmao Sun;Tianming Cui;Xinyu Guo;Changjian Xing;Zhengxiang Chen;Changyong Ji;Shuhang Liang;Shengwei Tao;Junhui Chu;Chenghui Wu;Qi Chu;Xuetian Gu;Ning Zhang;Yumin Fu;Shumin Deng;Yitong Zhu;Jiabei Wang;Yao Liu;Lianxin Liu,VCP downstream metabolite glycerol-3-phosphate (G3P) inhibits CD8+T cells function in the HCC microenvironment,2025-1-24,DOI:10.1038/s41392-024-02120-8
IF:40.8
链接：https://doi.org/10.1038/s41392-024-02120-8
产品：pAAV-CMV-VEGFA-T2A-mKate2（p10331）
Yuxuan Zhao; Meng Zhang; Wenting Zhang; Yao Zhou; Longbiao Chen; Qing Liu; Peng Wang; Rong Chen; Xinxin Duan; Feifan Chen; Huan Deng; Yunfei Wei; Peng Fei; Yu-Hui Zhang,Isotropic super-resolution light-sheet microscopy of dynamic intracellular structures at subsecond timescales,2022-3-11,DOI:10.1038/s41592-022-01395-5
IF:36.1
链接：https://doi.org/10.1038/s41592-022-01395-5
产品：pEnCMV-3×HA plasmids（P18147）
Yunkai Zhang; Ying Gao; Yujia Wang; Yuyu Jiang; Yan Xiang; Xiaohui Wang; Zeting Wang; Yingying Ding; Huiying Chen; Bing Rui; Wanwan Huai; Boyu Cai; Xiaomeng Ren; Feng Ma; Sheng Xu; Zhenzhen Zhan; Xingguang Liu,RBM25 is required to restrain inflammation via ACLY RNA splicing-dependent metabolism rewiring,2024-9-9,DOI:10.1038/s41423-024-01212-3
IF:21.8
链接：https://doi.org/10.1038/s41423-024-01212-3
Jian Xiao; Shuqing Cao; Jiawei Wang; Pengyu Li; Quan Cheng; Xinyi Zhou; Jiacheng Dong; Yuan Li; Xinyu Zhao; Zekuan Xu; Li Yang,Leptin-mediated suppression of lipoprotein lipase cleavage enhances lipid uptake and facilitates lymph node metastasis in gastric cancer,2023-11-30,DOI:10.1002/cac2.12583
IF:20.1
链接：https://doi.org/10.1002/cac2.12583
Yin-Wei Cheng; Fa-Min Zeng; Da-Jia Li; Shao-Hong Wang; Jian-Zhong He; Zhen-Chang Guo; Ping-Juan Nie; Zhi-Yong Wu; Wen-Qi Shi; Bing Wen; Xiu-E Xu; Lian-Di Liao; Zhi-Mao Li; Jian-Yi Wu; Jun Zhan; Hong-Quan Zhang; Zhi-Jie Chang; Kai Zhang; Li-Yan Xu; En-Min Li,P300/CBP-associated factor (PCAF)-mediated acetylation of Fascin at lysine 471 inhibits its actin-bundling activity and tumor metastasis in esophageal cancer,2021-1-1,DOI:10.1002/cac2.12221
IF:20.1
链接：https://doi.org/10.1002/cac2.12221
Yin-Wei Cheng; Fa-Min Zeng; Da-Jia Li; Shao-Hong Wang; Jian-Zhong He; Zhen-Chang Guo; Ping-Juan Nie; Zhi-Yong Wu; Wen-Qi Shi; Bing Wen; Xiu-E Xu; Lian-Di Liao; Zhi-Mao Li; Jian-Yi Wu; Jun Zhan; Hong-Quan Zhang; Zhi-Jie Chang; Kai Zhang; Li-Yan Xu; En-Min Li,P300/CBP-associated factor (PCAF)-mediated acetylation of Fascin at lysine 471 inhibits its actin-bundling activity and tumor metastasis in esophageal cancer,2021-1-1,DOI:10.1002/cac2.12221
IF:20.1
链接：https://doi.org/10.1002/cac2.12221
产品：pCMV-FGL1(human)-3×FLAG-Blast（p58521）
Ji Jiang; Pengfei Ye; Ningning Sun; Weihua Zhu; Mei Yang; Manman Yu; Jingjing Yu; Hui Zhang; Zijie Gao; Ningjie Zhang; Shijie Guo; Yuru Ji; Siqi Li; Cuncun Zhang; Sainan Miao; Mengqi Chai; Wenmin Liu; Yue An; Jian Hong; Huan Qiu; Shihao Zhang; Wei Wei,Yap methylation-induced FGL1 expression suppresses anti-tumor immunity and promotes tumor progression in KRAS-driven lung adenocarcinoma,2023-15,DOI:10.1002/cac2.12609
IF:20.1
链接：https://doi.org/10.1002/cac2.12609
Xin Zhang; Tao Li; Mengdi Yang; Dashan Tan; Bin Fu; Qianming Du; Yingying Tan; Mengran Cao; Chenyuan Xuan; Yaxin Chen; Rong Hu; Qing Wang,Intercellular adhesion molecule-1 suppresses TMZ chemosensitivity in acquired TMZ-resistant gliomas by increasing assembly of ABCB1 on the membrane,2024-6-24,DOI:10.1016/j.drup.2024.101112
IF:15.8
链接：https://doi.org/10.1016/j.drup.2024.101112
Xin Zhang; Tao Li; Mengdi Yang; Dashan Tan; Bin Fu; Qianming Du; Yingying Tan; Mengran Cao; Chenyuan Xuan; Yaxin Chen; Rong Hu; Qing Wang,Intercellular adhesion molecule-1 suppresses TMZ chemosensitivity in acquired TMZ-resistant gliomas by increasing assembly of ABCB1 on the membrane,2024-6-24,DOI:10.1016/j.drup.2024.101112
IF:15.8
链接：https://doi.org/10.1016/j.drup.2024.101112
Xin Zhang; Tao Li; Mengdi Yang; Dashan Tan; Bin Fu; Qianming Du; Yingying Tan; Mengran Cao; Chenyuan Xuan; Yaxin Chen; Rong Hu; Qing Wang,Intercellular adhesion molecule-1 suppresses TMZ chemosensitivity in acquired TMZ-resistant gliomas by increasing assembly of ABCB1 on the membrane,2024-6-24,DOI:10.1016/j.drup.2024.101112
IF:15.8
链接：https://doi.org/10.1016/j.drup.2024.101112
Zhuang Teng;Jianke Yang;Xiguang Chen;Ya Liu,Intranasal morphology transformation nanomedicines for long-term intervention of allergic rhinitis,2023-12-13,DOI:10.1021/acsnano.3c08752
IF:15.8
链接：https://doi.org/10.1021/acsnano.3c08752
产品：pBBR1MCS2-Tac-mCherry（p0676）
Xinyuan Yang;Jiali Yang;Zihan Ye;Guizhen Zhang;Weimin Nie;Hui Cheng;Mengyun Peng;Kaixiang Zhang;Junjie Liu;Zhenzhong Zhang;Jinjin Shi,Physiologically inspired mucin coated Escherichia coli Nissle 1917 enhances biotherapy by regulating the pathological microenvironment to improve intestinal colonization,2022-3-1,DOI:10.1021/acsnano.1c09681
IF:15.8
链接：https://doi.org/10.1021/acsnano.1c09681
Peng Xu; Simei Zhong; Yunfei Wei; Xinxin Duan; Meng Zhang; Wei Shen; Yan Ma; Yu-Hui Zhang,Surface-functionalized halo-tag gold nanoprobes for live-cell long-term super-resolution imaging of endoplasmic reticulum dynamics,2024-7-30,DOI:10.1021/acsnano.4c06138
IF:15.8
链接：https://doi.org/10.1021/acsnano.4c06138
产品：pEnCMV-PTGFRN(human)-3×FLAG(1同义突变)（p24421）
Yuanda Wan; Liren Li; Ruilin Chen; Jiajia Han; Qiyun Lei; Xiaodong Tang; Zhipeng Chen; Wenyu Wu; Shuwen Liu; Xingang Yao,Engineered extracellular vesicles efficiently deliver CRISPR-Cas9 ribonucleoprotein (RNP) to inhibit herpes simplex virus1 infection in vitro and in vivo,2023-7-31,DOI:10.1016/j.apsb.2023.10.004
IF:14.8
链接：https://doi.org/10.1016/j.apsb.2023.10.004
Xiong Chen; Jinfu Qian; Shiqi Liang; Jianchang Qian; Wu Luo; Yujuan Shi; Hong Zhu; Xiang Hu; Gaojun Wu; Xiaokun Li; Guang Liang,Hyperglycemia activates FGFR1 via TLR4/c-Src pathway to induce inflammatory cardiomyopathy in diabetes,2023-9-29,DOI:10.1016/j.apsb.2024.01.013
IF:14.8
链接：https://doi.org/10.1016/j.apsb.2024.01.013
Chen Yang;Huidie Xu;Dong Yang;Yunhao Xie;Mingrui Xiong;Yu Fan;XiKai Liu;Yu Zhang;Yushuo Xiao;Yuchen Chen;Yihao Zhou;Liangliang Song;Chen Wang;Anlin Peng;Robert B. Petersen;Hong Chen;Kun Huang;Ling Zheng,A renal YY1-KIM1-DR5 axis regulates the progression of acute kidney injury,2023-1-3,DOI:10.1038/s41467-023-40036-z
IF:14.7
链接：https://doi.org/10.1038/s41467-023-40036-z
Chen Yang;Huidie Xu;Dong Yang;Yunhao Xie;Mingrui Xiong;Yu Fan;XiKai Liu;Yu Zhang;Yushuo Xiao;Yuchen Chen;Yihao Zhou;Liangliang Song;Chen Wang;Anlin Peng;Robert B. Petersen;Hong Chen;Kun Huang;Ling Zheng,A renal YY1-KIM1-DR5 axis regulates the progression of acute kidney injury,2023-1-3,DOI:10.1038/s41467-023-40036-z
IF:14.7
链接：https://doi.org/10.1038/s41467-023-40036-z
Jiayu Jin;Yunquan He;Jieyu Guo;Qi Pan;Xiangxiang Wei;Chen Xu;Zhiyuan Qi;Qinhan Li;Siyu Ma;Jiayi Lin;Nan Jiang;Jinghua Ma;Xinhong Wang;Lindi Jiang;Qiurong Ding;Elena Osto;Xiuling Zhi;Dan Meng,BACH1 controls hepatic insulin signaling and glucose homeostasis in mice,2023-1-18,DOI:10.1038/s41467-023-44088-z
IF:14.7
链接：https://doi.org/10.1038/s41467-023-44088-z
产品：pLV3-CMV-MCS-TagBFP（p50405）
Jiayu Jin;Yunquan He;Jieyu Guo;Qi Pan;Xiangxiang Wei;Chen Xu;Zhiyuan Qi;Qinhan Li;Siyu Ma;Jiayi Lin;Nan Jiang;Jinghua Ma;Xinhong Wang;Lindi Jiang;Qiurong Ding;Elena Osto;Xiuling Zhi;Dan Meng,BACH1 controls hepatic insulin signaling and glucose homeostasis in mice,2023-1-18,DOI:10.1038/s41467-023-44088-z
IF:14.7
链接：https://doi.org/10.1038/s41467-023-44088-z
Baiwen Chen; Jiajia Hu; Xianting Hu; Huifang Chen; Rujuan Bao; Yatao Zhou; Youqiong Ye; Meixiao Zhan; Wei Cai; Hua-Bing Li,DENR controls JAK2 translation to induce PD-L1 expression for tumor immune evasion,2022-1-1,DOI:10.1038/s41467-022-29754-y
IF:14.7
链接：https://doi.org/10.1038/s41467-022-29754-y
产品：pCMV-T7-IGF2BP1(human)-3×FLAG-Neo（p41601）
Rong Li;Xijing Yan;Cuicui Xiao;Tingting Wang;Xuejiao Li;Zhongying Hu;Jinliang Liang;Jiebin Zhang;Jianye Cai;Xin Sui;Qiuli Liu;Manli Wu;Jiaqi Xiao;Haitian Chen;Yasong Liu;Chenhao Jiang;Guo Lv;Guihua Chen;Yingcai Zhang;Jia Yao;Jun Zheng;Yang Yang,FTO deficiency in older livers exacerbates ferroptosis during ischaemia/reperfusion injury by upregulating ACSL4 and TFRC,2023-4-30,DOI:10.1038/s41467-024-49202-3
IF:14.7
链接：https://doi.org/10.1038/s41467-024-49202-3
产品：pCMV-FTO(human)-3×FLAG-Puro（p41507）
Yajie Qian; Jing Wu; Weidong Yang; Ruining Lyu; Qiao You; Jingjing Li; Qin He; Yuan Zhuang; Wenmei Wang; Yong Wang; Yanan Zhu; Zhiwei Wu; Deyan Chen,FTO-associated osteoclastogenesis promotes alveolar bone resorption in apical periodontitis male rat via the HK1/USP14/RANK pathway,2025-2-11,DOI:10.1038/s41467-025-56615-1
IF:14.7
链接：https://doi.org/10.1038/s41467-025-56615-1
产品：pCMV-HK1(human)-FLAG-Neo（p27233）
Yajie Qian; Jing Wu; Weidong Yang; Ruining Lyu; Qiao You; Jingjing Li; Qin He; Yuan Zhuang; Wenmei Wang; Yong Wang; Yanan Zhu; Zhiwei Wu; Deyan Chen,FTO-associated osteoclastogenesis promotes alveolar bone resorption in apical periodontitis male rat via the HK1/USP14/RANK pathway,2025-2-11,DOI:10.1038/s41467-025-56615-1
IF:14.7
链接：https://doi.org/10.1038/s41467-025-56615-1
产品：pCMV-TAS2R14(human)-3×FLAG-Neo（p59532）
Yajie Qian; Jing Wu; Weidong Yang; Ruining Lyu; Qiao You; Jingjing Li; Qin He; Yuan Zhuang; Wenmei Wang; Yong Wang; Yanan Zhu; Zhiwei Wu; Deyan Chen,FTO-associated osteoclastogenesis promotes alveolar bone resorption in apical periodontitis male rat via the HK1/USP14/RANK pathway,2025-2-11,DOI:10.1038/s41467-025-56615-1
IF:14.7
链接：https://doi.org/10.1038/s41467-025-56615-1
Gao Shuai;Gao Lingyu;Yuan Dailin;Lin Xu'ai;van der Veen Stijn,Gonococcal OMV-delivered PorB induces epithelial cell mitophagy,2023-10-17,DOI:10.1038/s41467-024-45961-1
IF:14.7
链接：https://doi.org/10.1038/s41467-024-45961-1
Gao Shuai;Gao Lingyu;Yuan Dailin;Lin Xu'ai;van der Veen Stijn,Gonococcal OMV-delivered PorB induces epithelial cell mitophagy,2023-10-17,DOI:10.1038/s41467-024-45961-1
IF:14.7
链接：https://doi.org/10.1038/s41467-024-45961-1
Gao Shuai;Gao Lingyu;Yuan Dailin;Lin Xu'ai;van der Veen Stijn,Gonococcal OMV-delivered PorB induces epithelial cell mitophagy,2023-10-17,DOI:10.1038/s41467-024-45961-1
IF:14.7
链接：https://doi.org/10.1038/s41467-024-45961-1
产品：pGL3-Basic-PDK1(mouse)-promoter（p21786）
Zhuo Chen; Baocheng Wan; Hong Zhang; Lina Zhang; Rong Zhang; Lianxi Li; Yi Zhang; Cheng Hu; Fam172a Neu,Histone lactylation mediated by Fam172a in POMC neurons regulates energy balance,2024-11-8,DOI:10.1038/s41467-024-54488-4
IF:14.7
链接：https://doi.org/10.1038/s41467-024-54488-4
Yuhao Chen;Meng Du;Zhen Yuan;Zhiyi Chen;Fei Yan,Spatiotemporal control of engineered bacteria to express interferon-γ by focused ultrasound for tumor immunotherapy,2022-8-2,DOI:10.1038/s41467-022-31932-x
IF:14.7
链接：https://doi.org/10.1038/s41467-022-31932-x
Tu Yingfeng;Yang Qin;Tang Min;Gao Li;Wang Yuanhao;Wang Jiuqiang;Liu Zhe;Li Xiaoyu;Mao Lejiao;Jia Rui zhen;Wang Yuan;Tang Tie-shan;Xu Pinglong;Liu Yan;Dai Lunzhi;Jia Da,TBC1D23 mediates Golgi-specific LKB1 signaling,2024-2-13,DOI:10.1038/s41467-024-46166-2
IF:14.7
链接：https://doi.org/10.1038/s41467-024-46166-2
Jie Mo; Chen Su; Pengcheng Li; Zhenhua Yang; Ran Tao; Qiumeng Liu; Chaoyi Yuan; Lei Xu; Qianyun Ge; Deng Ning; Huifang Liang; Haidan Zhu; Yan Luo; Xiaoping Chen; Jin Chen; Bixiang Zhang,CKAP4 in hepatocellular carcinoma: competitive RETREG1/FAM134B binding, reticulophagy regulation, and cancer progression,2024-1-15,DOI:10.1080/15548627.2024.2435236
IF:14.6
链接：https://doi.org/10.1080/15548627.2024.2435236
产品：pLV3-CMV-EGFP-SEC61B(human)-Puro（p51269）
Jie Mo; Chen Su; Pengcheng Li; Zhenhua Yang; Ran Tao; Qiumeng Liu; Chaoyi Yuan; Lei Xu; Qianyun Ge; Deng Ning; Huifang Liang; Haidan Zhu; Yan Luo; Xiaoping Chen; Jin Chen; Bixiang Zhang,CKAP4 in hepatocellular carcinoma: competitive RETREG1/FAM134B binding, reticulophagy regulation, and cancer progression,2024-1-15,DOI:10.1080/15548627.2024.2435236
IF:14.6
链接：https://doi.org/10.1080/15548627.2024.2435236
产品：pLV3-CMV-HSP90B1(human)-3×HA-Puro（p58439）
Jie Mo; Chen Su; Pengcheng Li; Zhenhua Yang; Ran Tao; Qiumeng Liu; Chaoyi Yuan; Lei Xu; Qianyun Ge; Deng Ning; Huifang Liang; Haidan Zhu; Yan Luo; Xiaoping Chen; Jin Chen; Bixiang Zhang,CKAP4 in hepatocellular carcinoma: competitive RETREG1/FAM134B binding, reticulophagy regulation, and cancer progression,2024-1-15,DOI:10.1080/15548627.2024.2435236
IF:14.6
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